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There is an urgent need for more accurate imaging and noninvasive diagnosis
Current imaging options pose challenges in characterizing IRMs
Increased detection of indeterminate renal masses (IRMs) has led to an urgent need for more precise imaging.1
While CT and MRI are mainstays of renal imaging,1 they have several limitations.
- While CT and MRI reveal structural information about a tumor, neither can reliably characterize particularly aggressive tumors such as ccRCC2-4
- They lack the ability to detect the invasion of important renal structures including the renal capsule, which is critical for staging5
If conventional imaging fails to characterize a renal mass, biopsy may be the next step—but not for all patients6
When imaging reveals a tumor suggestive of RCC, a biopsy is warranted.1 However, some patients are not candidates for biopsy due to tumor location, size, and other patient factors such as age, having a single kidney, obesity, impaired kidney function, bleeding disorders, medications that increase bleeding risk, or other comorbid conditions.6
In a study of 18,060 patients,
≈
1/3
of partial nephrectomies revealed benign pathological findings7
A noninvasive, more accurate way to characterize IRMs may provide greater confidence to clinicians and patients and help inform management decisions
LEARN ABOUT CAIX TargetingCAIX, carbonic anhydrase IX; CT, computed tomography; MRI, magnetic resonance imaging; RCC, renal cell carcinoma.
References: 1. van Oostenbrugge TJ, Fütterer JJ, Mulders PFA. Diagnostic imaging for solid renal tumors: a pictorial review. Kidney Cancer. 2018;2(2):79-93. 2. Fried JG, Morgan MA. Renal imaging: core curriculum 2019. Am J Kidney Dis. 2019;73(4):552-565. 3. Roussel E, Capitanio U, Kutikov A, et al. Novel imaging methods for renal mass characterization: a collaborative review. Eur Urol. 2022;81(5):476-488. 4. Long Z, Sun C, Tang M, et al. Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma. Cell Discov. 2022;8(1):68. 5. Abou Elkassem AM, Lo SS, Gunn AJ, et al. Role of imaging in renal cell carcinoma: a multidisciplinary perspective. Radiographics. 2021;41(5):1387-1407. 6. de Silva S, Lockhart KR, Aslan P, et al. Differentiation of renal masses with multi-parametric MRI: the de Silva St George classification scheme. BMC Urol. 2022;22(1):141. 7. Kim JH, Li S, Khandwala Y, Chung KJ, Park HK, Chung BI. Association of prevalence of benign pathologic findings after partial nephrectomy with preoperative imaging patterns in the United States from 2007 to 2014. JAMA Surg. 2019;154(3):225-231.